Users can build upon the angiogenesis model in AIM DAX-1 chips to investigate factors that are anti-angiogenic. The inhibitors may include chemical entities, proteins, genetic regulators, mechanobiological factors, etc.
The DAX-1 chip design is suitable for anti-angiogenesis assays; however, the detailed protocols for the AIM chips are currently being developed. Please refer to the references below; these papers used PDMS versions of the chip to conduct anti-angiogenesis assays.
Users can submit their protocols to be referenced in this section and given due credit.
- Yamamoto, K., et al., The stabilization effect of mesenchymal stem cells on the formation of microvascular networks in a microfluidic device. Journal of Biomechanical Science and Engineering, 2013. 8(2): p. 114-128.
- Sharghi-Namini, S., et al., Dll4-containing exosomes induce capillary sprout retraction in a 3D microenvironment. Sci. Rep., 2014. 4.