Anti-Angiogenesis

Users can build upon the angiogenesis model in AIM DAX-1 chips to investigate factors that are anti-angiogenic. The inhibitors may include chemical entities, proteins, genetic regulators, mechanobiological factors, etc. 

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Protocols

The DAX-1 chip design is suitable for anti-angiogenesis assays; however, the detailed protocols for the AIM chips are currently being developed. Please refer to the references below;  these papers used PDMS versions of the chip to conduct anti-angiogenesis assays.

SHARE PROTOCOLS

Users can submit their protocols to be referenced in this section and given due credit.

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References

1. Yamamoto, K., et al., The stabilization effect of mesenchymal stem cells on the formation of microvascular networks in a microfluidic device. Journal of Biomechanical Science and Engineering, 2013. 8(2): p. 114-128.
2. Sharghi-Namini, S., et al., Dll4-containing exosomes induce capillary sprout retraction in a 3D microenvironment. Sci. Rep., 2014. 4.       

SUBMIT PAPERS

Users can submit their publications to be referenced in this section.